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Saw some interesting PET scans of human brains 18 months after taking vitamin B1 as benfotiamine 300mg. It was a small study, five patients. I can't find the pics but here's a small article about it https://www.ncbi.nlm.nih.gov/pubmed/27696179 " Benfotiamine significantly improved the cognitive abilities of mild to moderate AD patients independently of brain amyloid accumulation."